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Some scholars have confirmed that curcumin can reduce the expression of VEGF, inducible nitric oxide synthase (iNOS) and ICAM-1 by inhibiting the activation of CaMKII/NF-κB signaling in the diabetic rat retina and in Müller cells cultured in high glucose (71,72)
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The tirzepatide doses of 10 and/or 15 mg demonstrated superiority compared to placebo for the coprimary endpoints percentage body weight reductions from baseline at week 72 and the proportion of patients achieving ≥5% body weight reduction at week 72
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